Sinopsis

Nearly half of the world’s adult population is either clinically obese or overweight. Excess weight increases risk for multiple other chronic diseases and represents a major global health issue. Weight gain results from an imbalance between energyintake and expenditure, which can only be corrected if the physiologic and neuroendocrine systems that have the potential to control energy balance are identified.

The first edition of this book reviewed knowledge on the intake of micro- and macronutrients, food choice, and opposing views on whether or not there are mechanisms that control food intake. Appetite and Food Intake: Central Control, SecondEdition contains all new chapters and serves as a companion to the first by reviewing current knowledge on neuroendocrine mechanisms that influence food intake and glucose metabolism, including environmental influences on their development,with an emphasis on recent progress in understanding forebrain and hindbrain control of ingestive behavior.

In addition, there is a discussion on the benefits derived from novel models for exploring ingestive behavior and the progress that has been achieved due to new technologies. Although major progress is being made in understanding the complexinterplay between different control systems, the limits of our knowledge are acknowledged in chapters that review the efficacy of current weight control drugs and the relative importance of fat free mass and body fat in driving food intake.

Features

Provides overview of the importance of hindbrain in control of energy intake and glucose metabolism
Identifies contributions made by new technologies to understanding central control of food intake
Discusses advantages of novel models for studying ingestive behavior
Presents current knowledge on environmental factors that influence development of neural circuits controlling energy balance
Reviews current weight control drugs and current thinking on which aspect of body composition is controlled

Contents

Appetite control in C. elegans
Kristen Davis, Mi Cheong Cheong, Ji Su Park and Young-Jai You

Central and peripheral regulation of appetite and food intake in Drosophila
Audrey Branch and Ping Shen

The hamster as a model for human ingestive behavior
Ruth B.S. Harris

Beyond homeostasis: Understanding the impact of sychosocial factors on appetite using nonhuman primate models
Mark E Wilson and Vasiliki Michopoulos

Untangling appetite circuits with optogenetics and chemogenetics
Michael J. Krashes

The use of functional MRI in the study of appetite and obesity
Selin Neseliler, Jung-Eun Han, Alain Dagher

Development of hypothalamic circuits that control food intake and energy balance
Sebastien G. Bouret

Maternal and epigenetic factors that influence food intake and energy balance in offspring
Lin Song, Miranda D Johnson, and Kellie L Tamashiro

Monitoring and maintenance of brain glucose supply: importance of hindbrain catecholamine neurons in this multifaceted task
Sue Ritter

Hindbrain astrocyte glucodetectors and counter-regulation
Richard C. Rogers, David H. McDougal, and Gerlinda E. Hermann

Vagal afferent signaling and the integration of direct and indirect controls of food intake
Robert C. Ritter, Carlos A. Campos, Jason Nasse and James H. Peters

Energy metabolism and appetite control: Separate roles for fat-free mass and fat mass in the control of food intake in humans.
Mark Hopkins and John E Blundell

Pharmacotherapy for weight loss
Thomas A. Lutz and Lori Asarian