Sinopsis

Book initiates with introductory material to hemodialysis technology and its historical evolution and later on divulging into the field of biomaterials. With this background, the book discusses selection criteria of a suitable biomaterial for synthesis of haemodialysis membranes along with illustration of a complete indigenous, low cost technology for spinning of haemodialysis fibres. Well illustrated description of instruments used for membrane characterization and biomedical engineering is also provided at suitable junctures to effectively present the concept including worked out examples. Present title can be a good textbook as well as a research material for membrane as well as biomedical engineering curricula and provides coverage for appropriate undergraduate and graduate students interested in hemodialysis membranes.

Features

Presents a very thorough discussion of membrane technology in the context of hemodialysis
Describes mathematical models in predicting hemodialysers performance/hemodialysis
Connects the process to the material of construction for the process
Provides basic fundamental level concepts of membranes, instruments through simple worked out examples
Guide to understanding and developing membranes for biomedical applications

Contents

1.Kidney Function and Uremia

Kidney Function and Micturition

Quantifying Kidney Performance

Renal Failure : Types and Causes

Kidney Failure - Uremic Toxicity

Conclusion - Treatment for Renal Failure Patients

Evolution of Hemodialysis Technology

Hemodialysis Technology

Membrane technology

Hemodialysis - state of art and basics

Hemodialysis transport mechanisms

Hemodialysis membranes - material development

Conclusion

Biocompatibility and Biomaterials

Biocompatibility and Biomaterials - Definition

History of biomaterials

Essential properties of biomaterials

Biocompatibility in case of dialysis membranes

Essential Equipments for Analyzing Biocompatibility

Conclusion

Selection of Material for Dialysis Membrane

Introduction

Materials and Methods

Selection of best material

Comparison of present study with state of art literature

Conclusion

Spinning of Dialysis Grade Membranes

Introduction

Materials and Methods

Results and discussion

Conclusion

Post Processing of Dialysis Membranes

Introduction

Experimental Section

Results and discussion

Conclusion

Mathematical Modeling of Dialysis

Introduction

Mathematical models

Mathematical method to find post dialysis urea concentration

Regional Blood Flow (RBF) Model

Holistic View: Hemodialyzer Modeling

Conclusion

Economics of Dialyzer Manufacturing : Commercialization

Commercialization

Customer segmentation

Plant Layout, Design and Production

Business plan, key activities and key resources

Financial analysis

Prototypes developed

Conclusion

Conclusion : Future Trends and Scope

Future trends in dialysis research

Water Requirements and Standards

Dialyzer reuse and India

Dialyzer Reuse : Steps

Holistic Overview

Author(s) Bio

Dr. Sirshendu De is professor of Department of Chemical Engineering, Indian Institute of Technology Kharagpur (IIT KGP). He completed his undergraduate (1986-90), masters (1991-92) and PhD (1993-1997) degrees all from IIT Kanpur. Having completed his PhD he joined IIT KGP as Visiting Faculty in 1997 and rose to Associate Professor in 2002, finally becoming a Professor in 2007. Presently he is the Head of Department of Chemical Engineering. Prof. De is an eminent chemical engineer in India. He maintains national and international visibility through his innumerable international publications (232), patents (15), books (7) and book chapters (10) and 3 technology transfers. Apart from developing low cost spinning of both dialysis membranes as well as hollow fibers for water treatment and other industrial use, some of other innovations by Prof. De include ultra low cost filter for removal of arsenic from drinking water, extraction of polyphenols from green tea leaves and processing of packaged tender coconut water with high shelf life without any additive and preservative. Prof. De has been awarded with prestigious Shanti Swarup Bhatnagar (2011), the highest scientific honour of India. He has also been recipient of Innovation Award 2015 by Indian Desalination Association (south zone), National Award (Govt. of India) for Technology Innovation in various Field of Petrochemicals and Downstream Plastic Processing Industry – 2015, Department of Science and Technology (Govt. of India) - Lockheed Martin - Gold Medal - Top 10 Innovation Award 2015 - IC2 Business Development Support, NASI Reliance award (2013), Herdilia Awards (2010) to name a few. He is a fellow of INAE and NASI. Presently he is INAE Chair Professor and is serving as the Head of Department of Chemical Engineering.

Anirban Roy completed his undergraduate training in Chemical Engineering from Heritage Institute of Technology, Kolkata, in 2007 and Masters in Chemical Engineering from Jadavpur University, Kolkata in 2009. He had a brief stint as a research assistant at the University of Rhode Island from 2009-2011 and worked as a consultant engineer at M.N. Dastur and Co Pvt. Ltd for TATA Steel, Jindal and Vizag steel. He joined the PhD program at Department of Chemical Engineering, IIT Kharagpur, under the guidance of Prof. Sirshendu De, in 2012 and has been working on membrane separations with specialization on hemodialysis membranes. He is involved in developing the indigenous process design of hemodialysis grade hollow fibers as topic of his PhD dissertation. He has published 9 papers in international journals and has 10 conference publications (international and national). He has also filed 3 Indian and 1 US patent. Anirban has been the recipient of the "Young Innovator of India 2015" award in the Make In India conclave held at IIT Bombay, "National Award (Govt. of India)" for Technology Innovation in various Field of Petrochemicals and Downstream Plastic Processing Industry – 2015, Department of Science and Technology (Govt. of India) - Lockheed Martin - Gold Medal - Top 10 Innovation Award 2015 - IC2 Business Development Support, IChemE Global Award (Top 5 shortlist) for Dhirubhai Ambani Award for Outstanding Chemical Engineering Innovation for Resource-Poor People and Simulanis Research Challenge - Top 3 Innovations in India. His research interests include biomedical applications of membrane technologies, polymer blend thermodynamics, rheology and clarification of food products and water treatment.